Software

Making better tablets

The Gamlen® Dashboard quantifies good and bad compression mixes quickly and easily, and with minimal user input

Can you tell the difference?

Now anyone can – with the Gamlen® Dashboard

1. Tabletability

Will your product make a strong but porous tablet? Maximising tabletability is a key objective formulation and process development objective.

2. Compactibility

Is your product at risk of over-compression. Products with very high density are much more likely to result in capping. They are also slower to dissolve.

3 Lubrication problems

Measurement of take-off (detachment) and ejection force gives a warning of picking, sticking and capping. Products with very high density are much more likely to result in capping. They are also slower to dissolve.

4 Extended friability

The Extended friability test shows the effect of compaction pressure and density on tablet friability, an important indicator of packing and fi lm coating problems.

5 Representative of production behaviour

Our system has been validated against numerous manufacturing systems including Fette, Killian and Kikisui.

What are the differences?

The recently published USP Chapter <1062> Tablet Compaction Properties defi nes key Critical Quality Attributes for manufactured tablets. These are calculated from tablet compaction pressure, density and tensile fracture stress. The Gamlen® Dashboard system measures all of these parameters, and many more. Using our unique powderassessment system, the Gamlen® Dashboard displays how a formulation compares with industry norms for key parameters of compaction, lubrication and elastic recovery.

The display shows where your formulation sites in the universe of compacted products. The default confi guration shows industry norms; the limits shown can be confi gured to show your organisation’s particular requirements at no extra cost. The graphs automatically scale to show your formulation along with the confi guration ranges you use.

Measuring Critical Quality Attributes using the Gamlen® Dashboard Software

Compaction (PCA)

Breaking (TTA)

Detachment stress (also known as take-off force) is also related to lubrication. High detachment stress also results in tablet defects – picking and sticking

Tabletability is the response of the formulation to pressure. We maximise tabletability to get a robust tablet which will withstand handling

Ejection stress is a measure of how well lubricated the formulation. Poor lubrication results in tablet defects picking, sticking and capping

Compactability is the response of the formulation to porosity. We maximise porosity to reduce the risk of over compression which results in tablet defects like capping

E/D ratio is the ratio of the ejection to the detachment forces. Extreme values (high or low) are associated with problem formulations. The reasons for this are not yet clear

Compactability is the response of the formulation to density. We minimise density to maximise water penetration and dissolution rate
Detachment

Excessive elastic recovery causes capping in many products. We minimise elastic recovery by selecting the right excipients

How do we do it?

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