Making better tablets
The Gamlen® Dashboard quantiﬁes good and bad compression mixes quickly and easily, and with minimal user input
Can you tell the difference?
Now anyone can – with the Gamlen® Dashboard
Will your product make a strong but porous tablet? Maximising tabletability is a key objective formulation and process development objective.
Is your product at risk of over-compression. Products with very high density are much more likely to result in capping. They are also slower to dissolve.
3 Lubrication problems
Measurement of take-off (detachment) and ejection force gives a warning of picking, sticking and capping. Products with very high density are much more likely to result in capping. They are also slower to dissolve.
4 Extended friability
The Extended friability test shows the effect of compaction pressure and density on tablet friability, an important indicator of packing and ﬁ lm coating problems.
5 Representative of production behaviour
Our system has been validated against numerous manufacturing systems including Fette, Killian and Kikisui.
What are the differences?
The recently published USP Chapter <1062> Tablet Compaction Properties deﬁ nes key Critical Quality Attributes for manufactured tablets. These are calculated from tablet compaction pressure, density and tensile fracture stress. The Gamlen® Dashboard system measures all of these parameters, and many more. Using our unique powderassessment system, the Gamlen® Dashboard displays how a formulation compares with industry norms for key parameters of compaction, lubrication and elastic recovery.
The display shows where your formulation sites in the universe of compacted products. The default conﬁ guration shows industry norms; the limits shown can be conﬁ gured to show your organisation’s particular requirements at no extra cost. The graphs automatically scale to show your formulation along with the conﬁ guration ranges you use.
Measuring Critical Quality Attributes using the Gamlen® Dashboard Software
Detachment stress (also known as take-off force) is also related to lubrication. High detachment stress also results in tablet defects – picking and sticking
Tabletability is the response of the formulation to pressure. We maximise tabletability to get a robust tablet which will withstand handling
Ejection stress is a measure of how well lubricated the formulation. Poor lubrication results in tablet defects picking, sticking and capping
Compactability is the response of the formulation to porosity. We maximise porosity to reduce the risk of over compression which results in tablet defects like capping
E/D ratio is the ratio of the ejection to the detachment forces. Extreme values (high or low) are associated with problem formulations. The reasons for this are not yet clear
Compactability is the response of the formulation to density. We minimise density to maximise water penetration and dissolution rate
Excessive elastic recovery causes capping in many products. We minimise elastic recovery by selecting the right excipients