Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures
The paper describes how using the Gamlen Instrument to test tablets accurately predicted tableting failure at the commercial scale. The paper also discusses how this information will prove useful for scaling up production.
Analysis of PROSOLV® EASYtab with added Ascorbic Acid
How the D series (GPCA) can be used to characterize the properties of a powder by measuring a number of key compression parameters.
How to reduce the risk of tablet picking and sticking using the Gamlen D series
“The effect of lubricant concentration on tabletability, tablet ejection and detachment can be evaluated using the Gamlen D series. Also, it is possible to investigate which materials are better lubricated by sodium stearyl fumarate than by magnesium stearate.”
Formulating minitabs – a study of SmartEx™ – a cellulose derivative
How a D series was used to perform compaction studies on SmartEx, a commercial exicipent material. By using controlled compaction force, Gamlen Instruments was able to charaterise the behaviour of the excipient material when compressed into a tablet. The material performed very well.
Characterization of tableting properties measured with a multi-functional compaction instrument for several pharmaceutical excipients and actual tablet formulations
Before designing tablet formulations, it is important to understand the “Tableting Properties” of excipients and API (active pharmaceutical ingredient) powders. Those properties refer to “Compressibility”, “Compactability” and “Manufacturability”, which are difficult to evaluate quantitatively. The study evaluates “Tableting Properties” by using a Gamlen benchtop single-punch tablet press – developed to measure these parameters using a single device. The study confirmed the ability of the Gamlen device to evaluate the characteristics of typical pharmaceutical additives.
Development of orodispersible minitablets with lorazepam using Gamlen R series (formerly Gamlen Tablet Press GTP-1)
“Lorazepam is used for sedation in pediatric and neonatal units. At the moment, for children aged under 12 years, injection is the only available marketed preparation. This poster discusses research to explore the use of orodispersible minitablets as an age appropriate dosage form. Production on a Gamlen instrument was compared with a rotary press to demonstrate potential problems with product development. The poster also comments on the accuracy of the powder pipette down to 5 mg material. The minitablets made on the Gamlen instrument had a higher and more reproducible mechanical strength that the rotary press.”
Why material compressibility assessments are essential to tablet drug development and manufacture
The article explains how Gamlen instrument can produce emperical information that helps the formulation development process – saving time and money.
How drug supplier compressibility evaluation can help make informed decisions
Customer study to evaluate materials from different suppliers using less than 1g material per supplier.
How to improve tablet manufacturing process using rapid formulation assessments
Study using a well known blood pressure medicine to compare the existing wet granulated formulation with direct compression excipients. The results showed that the manufacturer could remove the wet granulation step in favour of using direct compression with either agglomerated or spray dried lactose – huge benefit to manufacturer in terms of process time and cost resulting in manufacturing efficiences.
Sawai Pharmaceuticals, Japan – Gamlen Instruments user group meeting 2017
Characterization of tableting properties measured with Gamlen R series for several pharmaceutical excipients and actual tablet formulations