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Early processability assessments during product development can help identify optimal API for efficient processing

The research team created 6 different crystalline forms of the same (single) API (supplied by Syntese). The aim of the research was to identify if the crystalline form affected the downstream flowability and tabletability of the API. Tabletability was assessed using a Gamlen instrument to provide direct compression of the API. The research identified that carrying out processibility research during the development of an API will identify optimal crystal forms (habits) of the API for efficient processing.

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