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Development of orodispersible minitablets with lorazepam using Gamlen R series (formerly Gamlen Tablet Press GTP-1)

“Lorazepam is used for sedation in pediatric and neonatal units. At the moment, for children aged under 12 years, injection is the only available marketed preparation. This poster discusses research to explore the use of orodispersible minitablets as an age appropriate dosage form. Production on a Gamlen instrument was compared with a rotary press to demonstrate potential problems with product development. The poster also comments on the accuracy of the powder pipette down to 5 mg material. The minitablets made on the Gamlen instrument had a higher and more reproducible mechanical strength that the rotary press.”

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